Animal Models of Disease
نویسنده
چکیده
Charles River’s Disease Models program supports these efforts by making rodent models available for the study of cardiovascular, metabolic and renal diseases and their related complications. Additionally, through our Discovery and Imaging Services and Preclinical Services groups we have extensive experience using multiple models and species within these therapeutic areas. GK (Goto-Kakizaki) Rat Strain Code: 460 Nomenclature: GK/TohiCskCrljCrl Therapeutic Area: Metabolic Control: Crl:WI (Wistar) Origin: The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain that develops adult onset type 2 diabetes early in life. This model was developed in the 1970s by Goto and associates at Tohoku University in Sendai, Japan, by selecting breeder pairs with the highest blood glucose levels (OGTT) from a colony of Wistar rats. Repeated selection of breeders based on OGTT resulted in glucose intolerance after five generations. To Charles River Japan from Chugai Pharmaceutical Co., in 1995. To Charles River North America in 2006. Characteristics: Non-Obese, Type 2 Diabetes, Hyperinsulinemia, Insulin Resistance, Mild Hyperglycemia, Neuropathy, Osteopathy, Retinopathy, Nephropathy. The GK rat is a non-obese, type 2 diabetes model.
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